Stratifying Gut Microbiomes by Succinotype: A Link to Inflammatory Bowel Disease

Introducing "succinotypes" — a groundbreaking classification of human gut microbiomes based on the bacteria that consume succinate, a crucial gut metabolite. We leveraged our innovative NicheMap™ approach to identify key bacterial players driving differences in succinate consumption rates across microbiomes.

This discovery establishes a direct connection between succinate metabolism and inflammatory diseases like IBD, positioning succinotypes as a functional biomarker and a promising therapeutic target for gut health.

Congratulations to Laura Anthamatten and the teams at ETH and PharmaBiome for showcasing the transformative potential of the NicheMap™!

Anthamatten, L. et al. Microbiome 30;12(1):186 (2024), 10.1080/19490976.2023.2177486